Molecular Formula (分子式):

C54H90N6O18

Molecular Weight (分子量)：

1111.32

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≥98%(TLC) & ≥95%(HPLC)

Solubility

用途

• 生物与化学科研领域

• 钾离子运输机制研究工具：它对钾离子具有极强的选择性亲和力，能结合钾离子形成脂溶性复合物帮助其穿过膜脂双层，常被用于研究细胞内外钾离子的运输规律，还可用于构建酸碱跃迁和钾离子 - 缬氨霉素扩散势所需的 pH 环境，助力解析生物膜的离子转运机制。同时也能用于平衡大肠杆菌、乳酸菌等菌株的胞内与胞外 pH 值，为相关微生物代谢研究提供条件。

• 离子敏感器件制备：以缬氨霉素为活性物质制作敏感膜，覆盖在氢离子敏感器件的绝缘栅表面，可研发出钾离子敏场效应晶体管（K⁺-sIFET）。这类器件稳定性好、灵敏度高且选择性强，在离子检测相关的电子器件领域具有应用价值。

• 手性分离固定相：其作为光学活性固定相，可应用于气相色谱、液相色谱以及毛细管电泳中。借助自身特殊的分子结构，能实现对手性化合物的拆分，为复杂混合物中手性物质的分离与检测提供支持。

• 生物医药领域

• 广谱抗菌抗病毒：它最初作为抗生素被分离，对结核分枝杆菌具有抗菌活性；同时还是高效抗病毒药物，对人类冠状病毒、SARS - CoV、布尼亚病毒、肠道病毒等多种病毒均有抑制作用，在抗病毒药物研究领域有潜在价值。

• 抗肿瘤相关研究与应用：作为线粒体自噬激活剂，它能破坏线粒体膜电位并诱导肿瘤细胞凋亡。将其掺入脂质体后，可降低自身毒性并增强抗肿瘤效果，在体外实验中对肝癌、卵巢癌、肺癌等多种肿瘤细胞均有显著抑制作用，体内实验也能抑制裸鼠体内的肿瘤生长。

• 农业领域缬氨霉素是具有杀虫活性的抗生素，从灰色链霉菌等菌株的培养液中可分离得到，其对蚊子幼虫有极强的抑制活性，同时还可用于杀灭线虫和蜡虫。此外，相关研究发现它还有作为植物生长调节剂的潜力，有望在农作物病虫害防治及生长调控方面进一步开发应用。

Function

1. Biological and Chemical Research Fields

1. Tool for Potassium Ion Transport Mechanism Studies: It exhibits extremely high selective affinity for potassium ions (K⁺), forming lipophilic complexes to facilitate K⁺ transport across lipid bilayers. Commonly used to investigate the transport rules of intracellular and extracellular K⁺, it also helps construct pH environments required for acid-base jumps and K⁺-valinomycin diffusion potentials, aiding in the elucidation of ion transport mechanisms in biological membranes. Additionally, it can balance the intracellular and extracellular pH of strains such as Escherichia coli and lactic acid bacteria, providing conditions for related microbial metabolism research.

2. Fabrication of Ion-Sensitive Devices: Using valinomycin as the active substance to prepare sensitive membranes, which are coated on the insulated gate surface of hydrogen ion-sensitive devices, enables the development of potassium ion-sensitive field-effect transistors (K⁺-sIFETs). These devices feature high stability, sensitivity, and selectivity, holding application value in the field of ion detection-related electronic devices.

3. Chiral Separation Stationary Phase: As an optically active stationary phase, it is applicable in gas chromatography (GC), liquid chromatography (LC), and capillary electrophoresis (CE). Leveraging its unique molecular structure, it can achieve the resolution of chiral compounds, supporting the separation and detection of chiral substances in complex mixtures.

2. Biomedical Field

1. Broad-Spectrum Antibacterial and Antiviral Activity: Initially isolated as an antibiotic, it exhibits antibacterial activity against Mycobacterium tuberculosis; it is also a highly effective antiviral agent, inhibiting various viruses including human coronaviruses, SARS-CoV, bunyaviruses, and enteroviruses, with potential value in antiviral drug research.

2. Antitumor Research and Applications: As a mitophagy activator, it disrupts mitochondrial membrane potential and induces tumor cell apoptosis. When incorporated into liposomes, it reduces its own toxicity and enhances antitumor efficacy. In vitro experiments have shown significant inhibitory effects on various tumor cells such as hepatocellular carcinoma, ovarian cancer, and lung cancer, while in vivo experiments have demonstrated inhibition of tumor growth in nude mice.

3. Agricultural FieldValinomycin is an insecticidal antibiotic that can be isolated from the culture broth of strains such as Streptomyces griseus. It exhibits extremely strong inhibitory activity against mosquito larvae and can also be used to kill nematodes and waxworms. Furthermore, relevant studies have revealed its potential as a plant growth regulator, holding promise for further development and application in crop pest control and growth regulation.

Structure (结构式):